Tumor Necrosis Factor-alpha

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

Also Known As:

Tumor Necrosis Factor; TNF-alpha; Cachectin-Tumor Necrosis Factor; TNF Superfamily, Member 2; TNFalpha; Cachectin Tumor Necrosis Factor; Tumor Necrosis Factor alpha; Cachectin; Tumor Necrosis Factor Ligand Superfamily Member 2

Carbohydrates: 22516
- Glycoconjugates: 1370
  - Glycoproteins: 25180
    - Tumor Necrosis Factor-alpha: 63069
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Intercellular Signaling Peptides and Proteins: 30151
    - Cytokines: 168239
      - Monokines: 213
        Tumor Necrosis Factor-alpha: 63069
      - Tumor Necrosis Factors: 155
        Tumor Necrosis Factor-alpha: 63069
  - Glycoproteins: 25180
    - Tumor Necrosis Factor-alpha: 63069
  - Blood Proteins: 12679
    - Tumor Necrosis Factor-alpha: 63069
- Peptides: 84029
  - Intercellular Signaling Peptides and Proteins: 30151
    - Cytokines: 168239
      - Monokines: 213
        Tumor Necrosis Factor-alpha: 63069
      - Tumor Necrosis Factors: 155
        Tumor Necrosis Factor-alpha: 63069
Biological Factors: 2560
- Intercellular Signaling Peptides and Proteins: 30151
  - Cytokines: 168239
    - Monokines: 213
      - Tumor Necrosis Factor-alpha: 63069
    - Tumor Necrosis Factors: 155
      - Tumor Necrosis Factor-alpha: 63069

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Disease

Drug/Important Bio-Agent (IBA)